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Practice News

 

Genetics and Age Related Macular Degeneration

Posted 2/22/2008

Medical News Today (2/21) reported that "led by researchers at Sainte-Justine Hospital and the Universite de Montréal," a team of scientists has hypothesized that a "deficiency of the CD36" receptor may be responsible for the dry form of age-related macular degeneration (AMD). Publishing their results in the February edition of the journal PLoS Medicine, Sylvain Chemtob, M.D., Ph.D., and colleagues, found that the deficient receptor prevents the eye from being able to evacuate "oxidized lipids," which "in turn accumulate and attack the layers beneath and over the retina -- thereby causing vision loss." For the study, the researchers "used mice and rat models to pinpoint the scavenger receptor responsible for retinal degeneration typical of dry AMD." The authors said that the discovery is likely to have "important implications for the development of new therapies."

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